Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1484-1492.DOI: 10.6023/cjoc201710005 Previous Articles     Next Articles



黄燕敏, 庞春玲, 杨春晖, 展军颜, 甘春芳, 庞丽萍, 刘晓兰, 崔建国   

  1. 广西师范学院化学与材料科学学院 南宁 530001
  • 收稿日期:2017-10-08 修回日期:2017-12-13 发布日期:2018-02-06
  • 通讯作者: 崔建国,
  • 基金资助:


Synthesis and Evaluation of Some New Aza-A-homocholesteryl-lactam Thiazole Derivatives as Anticancer Agents

Huang Yanmin, Pang Chunling, Yang Chunhui, Zhan Junyan, Gan Chunfang, Pang Liping, Liu Xiaolan, Cui Jianguo   

  1. College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001
  • Received:2017-10-08 Revised:2017-12-13 Published:2018-02-06
  • Contact: 10.6023/cjoc201710005
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21462009, 21562007), the Technology and Development Project of Nanning City (No. 20171125-5), the Guangxi Colleges and University Key Laboratory Foundation of Beibu Gulf Oil and Natural Gas Resource Effective Utilization (No. 2014KLOG09).

Using a testosterone as a raw material, a steroidal skelecton with A-homo-lactam was constructed. Then, some new aza-A-homocholesteryl-lactam thiazole derivatives were synthesized by modifying of the 17-hydroxyl and introducing of various heterocycles, and their structures were determined by IR, NMR and HRMS. The antiproliferative activity of the compounds against different carcinoma cells was assayed. The results show that some compounds display a distinct antiproliferative activity against tested cancer cells and are almost inactive to HEK293T cells.

Key words: testosterone, heterosteroids, aza-A-homocholesteryl-lactam thiazole derivatives, antiproliferative activity