Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (5): 1107-1118.DOI: 10.6023/cjoc201711027 Previous Articles     Next Articles

Reviews

超两亲分子在药物转运体系构筑中的应用

邵为, 刘昕, 王婷婷, 胡晓玉   

  1. 南京大学化学化工学院 江苏先进有机材料重点实验室 南京 210023
  • 收稿日期:2017-11-17 修回日期:2017-12-04 出版日期:2018-05-25 发布日期:2017-12-08
  • 通讯作者: 胡晓玉,E-mail:huxy@nju.edu.cn E-mail:huxy@nju.edu.cn
  • 基金资助:

    国家自然科学基金(No.21572101)资助项目.

Applications of Supramolecular Amphiphilc for the Construction of Drug Delivery Systems

Shao Wei, Liu Xin, Wang Tingting, Hu Xiao-Yu   

  1. Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chmeical Engineering, Nanjing University, Nanjing 210023
  • Received:2017-11-17 Revised:2017-12-04 Online:2018-05-25 Published:2017-12-08
  • Contact: 10.6023/cjoc201711027 E-mail:huxy@nju.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21572101).

Stimuli-responsive supramolecular drug delivery systems (SDDSs) self-assembled by supra-amphiphiles have received tremendous attentions in cancer therapy due to various advantages of SDDSs, such as enhanced drug bioavailability, prolonged blood circulation and retention time, improved drug stability and so on. The construction of smart supramolecular drug delivery systems based on the different structural characteristics of macrocyclic compounds are reviewed and their recent applications in anti-cancer drug delivery are described. Advantages and drawbacks of the current supramolecular drug delivery systems are also discussed, along with the opportunities and challenges in future.

Key words: supra-amphiphile, macrocycles, nanocarrier, drug delivery system