Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1454-1461.DOI: 10.6023/cjoc201712042 Previous Articles     Next Articles



苏瀛鹏, 石娅, 常兵兵, 吴丽丽, 种思颖, 张为钢, 黄丹凤, 王克虎, 胡雨来   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2017-12-28 修回日期:2017-12-28 发布日期:2018-02-28
  • 通讯作者: 苏瀛鹏,
  • 基金资助:


Chlorination of α-Cyanoketones and 1, 3-Dicarbonyl Compounds by Using Trichloroisocyanuric Acid as Chlorine Source

Su Yingpeng, Shi Ya, Chang Bingbing, Wu Lili, Chong Siying, Zhang Weigang, Huang Danfeng, Wang Kehu, Hu Yulai   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2017-12-28 Revised:2017-12-28 Published:2018-02-28
  • Contact: 10.6023/cjoc201712042
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21362033, 21502154) and the Gansu Provincial Science and Technology Program (No. 17JR5RA073).

The α-chlorination of α-substituted-α-cyano ketone compounds and 1,3-dicabonyl compounds is described. Using 0.34 equiv. trichloroisocyanuric acid as chlorine source, the chlorination can efficiently access at room temperature in a mild condition without additional oxidant or base. The chloride products can be obtained in a higher yield.

Key words: trichloroisocyanuric acid, chlorination reaction, α-cyanoketone