Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2231-2242.DOI: 10.6023/cjoc201806018 Previous Articles     Next Articles

Special Issue: 合成科学

Reviews

人工遗传改造生命体的防逃逸技术研究进展

孟凡康a,b, 娄春波a,b   

  1. a 中国科学院微生物生理与代谢工程重点实验室 国家微生物资源前期开发重点实验室 中国科学院微生物研究所 北京 100101;
    b 中国科学院大学 生命科学学院 北京 100149
  • 收稿日期:2018-06-13 修回日期:2018-08-08 出版日期:2018-09-25 发布日期:2018-08-22
  • 通讯作者: 娄春波 E-mail:louchunbo@im.ac.cn
  • 基金资助:

    国家自然科学基金(Nos.31470818,31722002)和科技部(No.2015CB910300)资助项目.

Research Progress in Biocontainment of Genetically Modified Organisms

Meng Fankanga,b, Lou Chunboa,b   

  1. a CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101;
    b College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100149
  • Received:2018-06-13 Revised:2018-08-08 Online:2018-09-25 Published:2018-08-22
  • Contact: 10.6023/cjoc201806018 E-mail:louchunbo@im.ac.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 31470818, 31722002) and Ministry of Science and Technology of the People's Republic of China (No. 2015CB910300).

With the rapid progress of synthetic biology and other related filed, there is a continuous growth of the applications of genetically modified organisms in many aspects, including industry, agriculture, health and environment. However, unintended release or uncontrolled propagation of these genetically modified organisms may cause significant side effects to the nature ecological environment. In order to eradicate the escaping problem and horizontal gene transfer between artificial and natural organisms, many researches have been focused on how to limit genetically modified organisms to a controlled environment. The research progress of biocontainment of genetically modified organisms mainly from three aspects of traditional biocontainment strategies, the orthogonalization of central dogma and the design of complex genetic networks is highlighted. It is believed that the advanced biocontainment technology would promote the further application of synthetic biology.

Key words: synthetic biology, genetically modified organisms, biosafety, orthogonal central dogma, genetic network