Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 786-792.DOI: 10.6023/cjoc201807053 Previous Articles     Next Articles



李彦忠, 齐思佳, 徐彦浩, 夏成才, 段桂运   

  1. 泰山医学院药学院 泰安 271000
  • 收稿日期:2018-07-28 修回日期:2018-10-09 发布日期:2018-10-26
  • 通讯作者: 段桂运
  • 基金资助:


Virtual Screening, Design, Synthesis and Biological Activity of Zika Virus Inhibitors

Li Yanzhong, Qi Sijia, Xu Yanhao, Xia Chengcai, Duan Guiyun   

  1. School of Pharmacy, Taishan Medical University, Taian 271000
  • Received:2018-07-28 Revised:2018-10-09 Published:2018-10-26
  • Contact: 10.6023/cjoc201807053
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81671395).

NS5 is a protein component which plays a main role in replication of Zika virus, and its component part-methyl-transferase (5M5B) is the central participants of virus replication and host innate immune response. So it is used as the preferred protein of potential antiviral drugs development. Using 5M5B as receptors and using its binding sites to screen with over 2 million small molecule compounds, the leading compounds of anti-Zika virus were obtained. The structural optimization, activity prediction, chemical synthesis and pharmacological activity of the leading compound were studied. All the synthesized compounds were characterized by 1H NMR and 13C NMR. The antiviral activity of compound 3a is better than that of ribavirin (IC50=(7.69±0.36) μmol·L-1 for 3a vs IC50=(8.15±0.42) μmol·L-1 for ribavirin).

Key words: ZIKV inhibitor, virtual screening, structure-activity relationship (SAR), structural transformation