Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2802-2807.DOI: 10.6023/cjoc201904057 Previous Articles     Next Articles

ARTICLE

咪唑并吡啶在离子液中环境友好型的C-3位硒化反应

王薪*(), 穆石强, 孙婷, 孙凯*()   

  1. 安阳师范学院 安阳 455000
  • 收稿日期:2019-04-24 修回日期:2019-06-12 出版日期:2019-10-25 发布日期:2019-07-09
  • 通讯作者: 王薪,孙凯 E-mail:wangx933@nenu.edu.cn;sunk468@nenu.edu.cn
  • 基金资助:
    国家自然科学基金(21801007);河南省教育厅创新团队资助项目(18IRTSTHN004);河南省教育厅创新团队资助项目(18HASTIT006)

Eco-friendly C-3 Selenation of Imidazo[1,2-a]pyridines in Ionic Liquid

Wang Xin*(), Mu Shiqiang, Sun Ting, Sun Kai*()   

  1. College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000
  • Received:2019-04-24 Revised:2019-06-12 Online:2019-10-25 Published:2019-07-09
  • Contact: Wang Xin,Sun Kai E-mail:wangx933@nenu.edu.cn;sunk468@nenu.edu.cn
  • Supported by:
    Project supported by the National Natural Science Foundation of China(21801007);The Program for Innovative Research Team of Science and Technology in the University of Henan Province(18IRTSTHN004);The Program for Innovative Research Team of Science and Technology in the University of Henan Province(18HASTIT006)

An relative eco-friendly protocol for the direct C-3 selenation of imidazo[1,2-a]pyridines with vorious organoselenides has been developed, gaving the desired products in moderate to excellent yields. Preliminary experimental results are consistent with a C-3 electrophilic functionalization mechanism. The features with relative green reaction conditions, broad substrate scope, and easy scale-up operation would make this strategy promising and important for the preparation of nitrogen and selenium containing molecules.

Key words: selenation, imidazo[1,2-a]pyridines, C-3 functionalization, electrophilic mechanism