Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3475-3482.DOI: 10.6023/cjoc201905051 Previous Articles     Next Articles

Special Issue: 元素有机化学合辑2018-2019

一种β,β,β-二氟碘-1-苯基乙醇类化合物的简便合成方法

黄国志, 任洁, 郑笑笑, 吴范宏, 吴晶晶   

  1. 上海应用技术大学化学与环境工程学院 上海 201418
  • 收稿日期:2019-05-30 修回日期:2019-07-28 出版日期:2019-12-25 发布日期:2019-08-07
  • 通讯作者: 吴范宏, 吴晶晶 E-mail:wjj_693@163.com;wfh@sit.edu.cn
  • 基金资助:
    国家自然科学基金面上(No.21672151)资助项目.

A Convenient Synthesis of β,β-Difluoro-β-iodo-1-phenylethan-1-ols

Huang Guozhi, Ren Jie, Zheng Xiaoxiao, Wu Fanhong, Wu Jingjing   

  1. School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418
  • Received:2019-05-30 Revised:2019-07-28 Online:2019-12-25 Published:2019-08-07
  • Supported by:
    Project supported by the General Project of the National Natural Science Foundation of China (No. 21672151).

The synthesis of α,α,α-iodo-difluoromethyl alcohols via the high selective reduction of iododifluoromethyl ketones by NaBH4 in methanol at 0℃ was reported. The reaction has some advantages, such as mild condition, simple synthetic route, and high yield. A convenient way to synthesize more difluoromethylation agents was provided.

Key words: iodo-difluoromethyl ketones, NaBH4, iodo-difluoromethyl alcohol, selective reduction