Study on the Hydrocyanation Reaction of Trifluoromethylated Acylhydrazones

doi:10.6023/cjoc201910011

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (4): 922-929.DOI: 10.6023/cjoc201910011 Previous Articles Next Articles

三氟甲基酰腙的氰基化反应研究

徐炜刚, 黄丹凤, 王克虎, 赵芳霞, 赵转霞, 虎永琴, 苏瀛鹏, 胡雨来

西北师范大学化学化工学院兰州 730070

收稿日期:2019-10-11 修回日期:2019-12-10 发布日期:2019-12-27
通讯作者: 胡雨来 E-mail:huyl@nwnu.edu.cn
基金资助:
国家自然科学基金（Nos.21662030，21861033）资助项目.

Study on the Hydrocyanation Reaction of Trifluoromethylated Acylhydrazones

Xu Weigang, Huang Danfeng, Wang Kehu, Zhao Fangxia, Zhao Zhuanxia, Hu Yongqing, Su Yingpeng, Hu Yulai

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received:2019-10-11 Revised:2019-12-10 Published:2019-12-27
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21662030, 21861033).

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Abstract

The Lewis acid catalyzed 1,2-addition reaction of trifluoromethylated acylhydrazones with trimethylsilyl cyanide was investigated, and a series of cyanohydrazide compounds containing trifluoromethyl group were afforded in high yield. The method could be easily operated in mild reaction conditions, which provides an efficient method for the synthesis of trifluoromethylated hydrazides with structural diversity.

Key words: trifluoromethylated acylhydrazones, trimethylsilyl cyanide, acylhydrazides, hydrocyanation

Cite this article

Xu Weigang, Huang Danfeng, Wang Kehu, Zhao Fangxia, Zhao Zhuanxia, Hu Yongqing, Su Yingpeng, Hu Yulai. Study on the Hydrocyanation Reaction of Trifluoromethylated Acylhydrazones[J]. Chinese Journal of Organic Chemistry, 2020, 40(4): 922-929.

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三氟甲基酰腙的氰基化反应研究

Study on the Hydrocyanation Reaction of Trifluoromethylated Acylhydrazones

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