Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (4): 1337-1358.DOI: 10.6023/cjoc202009031 Previous Articles     Next Articles



王宇a, 王泾洋a, 吴啸宇a, 丁广妮b, 张兆国a,*(), 谢小敏a,*()   

  1. a 上海交通大学化学化工学院 上海 200240
    b 南昌大学材料科学与工程学院 南昌 330031
  • 收稿日期:2020-09-13 修回日期:2020-10-28 发布日期:2020-11-19
  • 通讯作者: 张兆国, 谢小敏
  • 作者简介:
    † 共同第一作者(These authors contributed equally to this work).
  • 基金资助:
    国家自然科学基金(21672143); 上海交通大学医工交叉(YG2017MS26)

Advances in Deallylation

Yu Wanga, Jingyang Wanga, Xiaoyu Wua, Guangni Dingb, Zhaoguo Zhanga,*(), Xiaomin Xiea,*()   

  1. a School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240
    b School of Materials Science and Engineering, Nanchang University, Nanchang 330031
  • Received:2020-09-13 Revised:2020-10-28 Published:2020-11-19
  • Contact: Zhaoguo Zhang, Xiaomin Xie
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    National Natural Science Foundation of China(21672143); Interdisciplinary Program of Shanghai Jiao Tong University(YG2017MS26)

Allyl groups, as a kind of universal protective groups in organic synthesis, are easily introduced, and stable under acidic, basic and reductive conditions. Moreover, the deallylation may occur efficiently and selectively under mild conditions. Therefore, functional group protection with allyl moiety plays a significant role in organic synthesis, especially in the synthesis of natural products and pharmaceutical industry. In recent decades, various methods of deallylation have been developed. Herein, the comprehensive development on the deallylation reaction with base and reductant, oxidation and free radical, Lewis-acid, iodine, transition metals, and electrochemical methods is reviewed.

Key words: deallylation, base-catalyzed deallylation, transition metal catalyzed deallylation, oxidative deallylation, free radical deallylation, Lewis-acid catalyzed deallylation, electrochemical deallylation