Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (6): 2511-2514.DOI: 10.6023/cjoc202012045 Previous Articles     Next Articles



李钰婷, 仝雪利, 田立文*()   

  1. 南方医科大学药学院 广州 510515
  • 收稿日期:2020-12-27 修回日期:2021-01-28 发布日期:2021-02-26
  • 通讯作者: 田立文
  • 基金资助:

A New Tirucallane Triterpenoid from Galla chinensis

Yuting Li, Xueli Tong, Liwen Tian()   

  1. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515
  • Received:2020-12-27 Revised:2021-01-28 Published:2021-02-26
  • Contact: Liwen Tian
  • Supported by:
    National Natural Science Foundation of China(81703381)

A new tirucallane triterpenoid was isolated from the ethyl acetate extract of Galla chinensis, along with five known tirucallane triterpenoids. Their structures were elucidated by extensive spectrosopic data analysis. It is the first time to report triterpenoids from G. chinensis. Masticadienonic acid (3), isomasticadienonic acid (4) and masticadienolic acid (5) showed neuroprotective activity at a concentration of 1.6 μmol•L –1. This study provides a structure template for neuroprotection agent discovery.

Key words: Galla chinensis, tirucallane triterpenoid, neuroprotective activity