Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis

doi:10.6023/cjoc202100042

Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (6): 2517-2519.DOI: 10.6023/cjoc202100042 Previous Articles Next Articles

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铱和手性硫脲串联催化的仲酰胺不对称还原氰基化和还原磷酰化反应

李照坤(), 王晓明^*

中国科学院上海有机化学研究所金属有机化学国家重点实验室上海 200032

发布日期:2021-07-07
通讯作者: 王晓明

Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis

Zhaokun Li(), Xiaoming Wang

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Published:2021-07-07
Contact: Xiaoming Wang

Cite this article

Zhaokun Li, Xiaoming Wang. Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis[J]. Chinese Journal of Organic Chemistry, 2021, 41(6): 2517-2519.

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Fig. & Tab. 4

Figure 1. Representative pharmaceuticals and natural products containing chiral α-aminonitriles and α-aminophosphonic acids

Scheme 1. Reductive functionalization of amides

Scheme 2. Examples of the reaction scope

Scheme 3. Transformations of chiral α-functionalized amines

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铱和手性硫脲串联催化的仲酰胺不对称还原氰基化和还原磷酰化反应

Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis

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