Chin. J. Org. Chem. ›› 1983, Vol. 3 ›› Issue (6): 451-453. Previous Articles     Next Articles

简法合成甲地孕酮

倪元;张水泉;余新娣;蔡祖恽   

  1. 中国科学院上海有机化学研究所;上海第十二制药厂
  • 发布日期:1983-12-25

A simple synthetic route for Δ6-6-methyl-17α-acetoxy-progesterone (megestrol acetate)

NI YUAN;ZHANG SHUIQUAN;YU XINDI;CAI ZUYUN   

  • Published:1983-12-25

A Simple synthetic route for megestrol acetate is reported. The key intermediate C6-methylene steroid may be obtained either from enol ether of 17α-acetoxy-progesterone by Mannich reaction, or from Δ3,5-3,17α-diacetoxy-progesterone ty treatment with C2H5OCH2OC2H5. Then the intermediate is isomerized with Pd/CaCO3 in the presence of cyclohexene and sodium acetate

Key words: STEROIDS, CONTRACEPTIVE, MEGESTROLI ACETAS

CLC Number: