Synthesis of plant growth inhibitor-paclobutrazol by phase transfering method

Abstract

(2RS,3RS)-1-p-Chlorophenyl-2-(1,2,4-triazol-1-yl)-4,4-dimethylpentan-3 -ol (Paclobutrazol) (I) was synthesized by phase transfering method. Chloropinacolone was reacted with 1,2,4-triazole to produce a-triazolylpinacolone, which was further reacted with p-chlorobenzyl halide and finally reduced by KBH4 to yield I. Phase-transfer catalyst, e.g., 18-crown-6, was used in all 3 steps.

Key words: POLYETHYLENE OXIDE, BENZENE P, PHASE TRANSFER CATALYSIS, PLANT GROWTH RETARDANT, BACTERICIDAL AGENTS, PYRRODIAZOLE P, PENTANOL P, PACLOBUTRAZOL

CLC Number:

TQ452

Cite this article

LIAO LIANAN;ZHANG HONGKUI;GUO QIZHEN. Synthesis of plant growth inhibitor-paclobutrazol by phase transfering method[J]. Chin. J. Org. Chem., 1986, 6(4): 291-294.

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以相转移方法合成植物生长抑制剂-Paclobutrazol