Chin. J. Org. Chem. ›› 1986, Vol. 6 ›› Issue (6): 443-446. Previous Articles     Next Articles

4-氨甲酰基-5-羟基取代α-甲基肉桂酸咪唑酯的合成

岳崇伟;李正化   

  1. 华西医科大学药学系
  • 发布日期:1986-12-25

Syntheses of 4-carbamoylimidazole-5-hydroxyl substituted \a\-methylcinnamates

YUE CHONGWEI;LI ZHENGHUA   

  • Published:1986-12-25

Title compounds I [R = H, 4-Cl, 3-Cl, 4-Br, 4-F, 4-Me, 4-MeO, 4-MeSO2, 2,4-Cl2, 3,4-CH2O2, 3,4,5-(MeO)3] were prepared in 45-77% yields from the imidazole II and the corresponding a-methylcinnamoyl chlorides. I showed hemolysin formation inhibitor activity at 0.2 mmol/kg in mice.

Key words: IMIDAZOLE P, ESTERS, ANTICARCINOGEN, IMMUNOSUPPRESSION, PHENYLACRYLIC ACID P, GLYCOSIDE

CLC Number: