Chin. J. Org. Chem. ›› 1992, Vol. 12 ›› Issue (2): 177-183. Previous Articles     Next Articles

Original Articles

一叶秋碱全合成的研究-中间体α-羟酮的合成

奚凤德;牛川生;梁晓天   

  1. 中国医学科学院药物研究所
  • 发布日期:1992-04-25

The synthesis of α-ketol, a relay compound for the construction of securinine

XI FENGDE;NIU CHUANSHENG;LIANG XIAOTIAN   

  • Published:1992-04-25

a-Ketol I, an intermediate in the total synthesis of securinine, was prepared in 7 steps starting from 3-chloroadipic acid. The key steps were acyloin reaction of silyl ether II and cyclization of cyclohexanone III.

Key words: C13 NMR SPECTROMETRY, INFRARED SPECTROPHOTOMETRY, PROTON MAGNETIC RESONANCE SPECTROMETRY, HEXANEDIOIC ACID P, PIPERIDINE

CLC Number: