Synthesis of 1-aroyl-3-(4-benzosulfonamidopyrimidine)-thioureas

Chin. J. Org. Chem. ›› 1993, Vol. 13 ›› Issue (3): 250-252. Previous Articles Next Articles

Original Articles

1-芳酰基-3-(4-苯磺酰胺嘧啶)硫脲类化合物的合成

贾学顺;王玉炉;李用芳;何芳淑;单英方

河南师范大学化学系;河南师范大学生物系

发布日期:1993-06-25

Synthesis of 1-aroyl-3-(4-benzosulfonamidopyrimidine)-thioureas

JIA XUESHUN;WANG YULU;LI YONGFANG;HE FANGSHU;SHAN YINGFANG

Published:1993-06-25

Abstract

A series of new 1-aroyl-3-(4-benzosulfonamidopyrimidine)-thioureas I (R = H, Me, Br, Cl, iodo) were synthesized by the reaction of aroyl isothiocyanate with sulfadiazine in anhydrous acetonitrile. Preliminary biol. tests indicate that some of compounds I possess marked inhibiting activity against Bacillus coli, Bacillus subtilis, proteus, and Staphylococcus aureus at concentration of 10 ppm.

Key words: BACILLUS SUBTILIS, STAPHYLOCOCCIN, ACETONITRILE, ADDITION REACTION, THIOUREAS, SULFADIAZINE, ISOTHIOCYANATE, ESCHERICHIA COLI

CLC Number:

O621

Cite this article

JIA XUESHUN;WANG YULU;LI YONGFANG;HE FANGSHU;SHAN YINGFANG. Synthesis of 1-aroyl-3-(4-benzosulfonamidopyrimidine)-thioureas[J]. Chin. J. Org. Chem., 1993, 13(3): 250-252.

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1-芳酰基-3-(4-苯磺酰胺嘧啶)硫脲类化合物的合成

Synthesis of 1-aroyl-3-(4-benzosulfonamidopyrimidine)-thioureas

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