Chin. J. Org. Chem. ›› 2003, Vol. 23 ›› Issue (2): 192-194. Previous Articles     Next Articles

一种简易的光活性1,1′-联二萘酚合成方法

施秀芳;张明杰;杜伟奇   

  1. 天津大学理学院化学系.天津(300072);安阳地区医院制剂室,安阳(455000)
  • 发布日期:2003-02-25

A facile synthesis of optically active 1,1′-binaphthol

Shi Xiufang;Zhang Mingjie;Du Weiqi   

  1. Department of Chemistry,Tianjin University.Tianjin(300072); Pharmacy,Anyang Regional Hospital,Anyang(455000)
  • Published:2003-02-25

The paper provides a practical, inexpensive method of resolution of 1,1'-binaphthol with the reagents L-TAC (tartaric acid)-TMEDA and L- PAC (proline) -TMEDA, in addition to an efficient enantioselectively aerobic oxidative self-coupling of 2-naphthol by catalysis of 1.5 mol % of PTCu, a chiral catalyst, which prepared from L-PAC, TMEDA and CuCl. The catalyst can directly be recycled without further activation.

Key words: NAPHTHALENOL P;OXIDATION;COUPLING REACTION;ASYMMETRICAL SYNTHESIS, TARTARIC ACID

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