Chin. J. Org. Chem. ›› 2005, Vol. 25 ›› Issue (11): 1494-1497. Previous Articles     Next Articles

Reports

格氏试剂异构偶联法合成辅酶Q10

李全*,古昆,程晓红   

  1. (云南大学应用化学系 生物制药创新人才培养基地 昆明 650091)
  • 收稿日期:2005-05-15 修回日期:2005-09-05 发布日期:2005-10-30
  • 通讯作者: 李全

Synthesis of Coenzyme Q10 via Isocoupling Reaction between Allylic Grignard Reagent and Allyl Halides

LI Quan*,GU Kun,CHENG Xiao-Hong   

  1. (Department of Applied Chemistry, Yunnan University, Kunming 650091)
  • Received:2005-05-15 Revised:2005-09-05 Published:2005-10-30
  • Contact: LI Quan

Coenzyme Q10 was synthesized by the isocoupling reaction between Grignard reagent of 2-methyl-3-chloro-4-(2'-methyl-3',4',5',6'-tetramethoxyphenyl)butene and solanesyl bromide followed by oxidation of the corresponding toluene derivative. It is therefore successfully indicated that allylic Grignard reagent can be isocoupled with allyl halide via a six-membered ring as transition state.

Key words: Grignard reagent, isocoupling, solanesol, coenzyme Q10