Chin. J. Org. Chem. ›› 2009, Vol. 29 ›› Issue (07): 1105-1114. Previous Articles     Next Articles

Original Articles

苯乙烯基喹啉磺酰胺衍生物的设计、合成与 HIV整合酶抑制活性的研究

曾程初* ; 牛丽亭; 平大为; 钟儒刚   

  1. (北京工业大学生命科学与生物工程学院 北京 100124)
  • 收稿日期:2008-09-18 修回日期:2008-12-06 出版日期:2009-07-22 发布日期:2009-07-22
  • 通讯作者: 曾程初

Design and Synthesis of 2-Styrylquinoline-7-sulfonamide Derivatives as Potential HIV Integrase Inhibitors

Zeng, Chengchu* ; Niu, Liting; Ping, Dawei; Zhong, Rugang   

  1. (College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124)
  • Received:2008-09-18 Revised:2008-12-06 Online:2009-07-22 Published:2009-07-22
  • Contact: Zeng, Chengchu

According to the steric, electrostatic and H-bonding features of the CoMFA model which was stemmed from the investigation of 38 2-styrylquinoline derivatives, a series of 2-styrylquinoline-7-sulfonamide derivatives were synthesized and evaluated as potential HIV integrase inhibitors. The structures of all compounds were characterized by NMR, IR, ESI-MS and HRMS techniques.

Key words: 2-styrylquinoline-7-sulfonamide, Perkin reaction, HIV integrase inhibitor