Chin. J. Org. Chem. ›› 2010, Vol. 30 ›› Issue (06): 918-922.
Hao Baoyu1,2 Chen Xinzhi*,1 Zhang Weihan2
An efficient route to synthesize 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (6) and 2,4-dichloro-7H- pyrrolo[2,3-d]pyrimidine (10) starting from diethyl malonate in five steps with the total yields of 45.8% and 44.8% was disclosed in the presented paper. The chemical structures of the objective products as well as the related intermediates were confirmed.
郝宝玉 Hao Bao-Yu XinZhi Chen Wei-Han Zhang. Synthesis of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine and 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine[J]. Chin. J. Org. Chem., 2010, 30(06): 918-922.
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