Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (08): 1388-1400.DOI: 10.6023/cjoc1112081 Previous Articles     Next Articles



尹晓娟a,b, 闫俊a,b, 姬胜利a,b, 王凤山a,b, 曹鸿志a   

  1. a 山东大学国家糖工程技术研究中心 济南 250012;
    b 山东大学药学院 济南 250012
  • 收稿日期:2011-12-08 修回日期:2012-02-15 发布日期:2012-03-09
  • 通讯作者: 姬胜利, 王凤山, 曹鸿志;;
  • 基金资助:

    国家自然科学基金(Nos. 20902087, 21172135)和国家重点基础研究发展规划(973计划, No. 2012CB822102)资助项目.

Recent Advances in the Synthesis of Heparan Sulfate Oligosaccharides

Yin Xiaojuana,b, Yan Juna,b, Ji Shenglia,b, Wang Fengshana,b, Cao Hongzhia   

  1. a National Glycoengineering Research Center, Shandong University, Jinan 250012;
    b School of Pharmaceutical Science, Shandong University, Jinan 250012
  • Received:2011-12-08 Revised:2012-02-15 Published:2012-03-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20902087, 21172135) and the National Basic Research Program of China (973 program, No. 2012CB822102).

Heparin (HP) and heparan sulfate (HS), a member of the glycosaminoglycan (GAG) family, are structurally related linear polyanionic polysaccharides. These complex sulfated polysaccharides can interact with hundreds of proteins and play essential roles in mediating or modulating a variety of physiological and pathological processes. Accumulated evidence has shown that the biological functions of HP and HS can be critically dependent upon their precise structure sequences. To decipher the sequence code of HS and HP, many research groups have focus on the development of novel strategies and synthetic methods for the assembling of heparin oligosaccharides during the last decade. The key developments since 2001 in the chemical or chemoenzymatic synthesis of heparin oligosaccharides are covered in this review.

Key words: heparin, heparan sulfate, chemical glycosylation, glycotransferase