Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (6): 1206-1211.DOI: 10.6023/cjoc201401009 Previous Articles     Next Articles



杨晓英a, 谭广慧a,b, 曲凤玉a,b, 金英学a, 王进军c   

  1. a. 哈尔滨师范大学化学化工学院 哈尔滨 150025;
    b. 哈尔滨师范大学生命科学技术学院 哈尔滨 150025;
    c. 烟台大学化学化工学院 烟台 264005
  • 收稿日期:2014-01-08 修回日期:2014-02-11 发布日期:2014-03-10
  • 通讯作者: 金英学, 王进军
  • 基金资助:

    国家自然科学基金(Nos. 21272048,21171045)和黑龙江省高效科技创新团队建设计划(No. 2011TD010)资助项目.

Synthesis of Phenylhydrazone and Amino acid Schiff Base of Pyropheophorbide-a

Yang Xiaoyinga, Tan Guanghuia,b, Qu Fengyua,b, Jin Yingxuea, Wang Jinjunc   

  1. a. College of Chemistry & Chemical Engineering, Harbin Normal University, Harbin 150025;
    b. College of Life Science and Biotechnology, Haerbin Normal University, Harbin 150025;
    c. College of Chemistry and Chemical Engineering, Yantai University, Yantai 264005
  • Received:2014-01-08 Revised:2014-02-11 Published:2014-03-10
  • Supported by:

    Project supported by the National Natural Sciences of Foundation of China (Nos. 21272048, 21171045), and the Program for Scientific Technological Innovation, Team Construction in Universites of Heilongjiang Province (No. 211TD010).

Methyl pyropheophorbide-a was used as starting material for the synthesis of phenylhydrazone and amino acid Schiff base by reactions of carbonyl group at 131-position. The maximum absorption wavelength of phenylhydrazone caused a red shift. The water-solubility of Schiff base was incremented, and the maximum absorption wavelength shifted hypsochromically. The structures of all these compounds were characterized by 1H NMR, MS and elemental analysis.

Key words: photodynamic therapy (PDT), methyl pyropheophorbide-a (Mppa), phenylhydrazone, amino acid, Schiff base, water-soluble