Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (6): 1348-1352.DOI: 10.6023/cjoc201412035 Previous Articles     Next Articles



郭生梅, 龚久涵, 卢林, 朱正, 蔡琥   

  1. 南昌大学化学学院 南昌 330031
  • 收稿日期:2014-12-20 修回日期:2015-02-02 发布日期:2015-02-10
  • 通讯作者: 蔡琥
  • 基金资助:

    国家重点基础研究发展计划(973计划, No. 2012CBA01204)和国家自然科学基金(No. 21302084)资助项目.

Synthesis of Methylene-Bridged Bis-1,3-dicarbonyl Compounds under Aerobic Condition

Guo Shengmei, Gong Jiuhan, Lu Lin, Zhu Zheng, Cai Hu   

  1. College of Chemistry, Nanchang University, Nanchang 330031
  • Received:2014-12-20 Revised:2015-02-02 Published:2015-02-10
  • Supported by:

    Project supported by the National Key Basic Research Program of MOST of China (973 Program, No. 2012CBA01204) and the National Natural Science Foundation of China (No. 21302084).

A simple route for the preparation of methylene-bridged bis-1,3-dicarbonyl compounds was achived through a cleavage of C—N bond of tertiary amines. In this reaction, tetramethylethylenediamine (TMEDA) was used as the methylene source, and cuprous iodide as catalyst under aerobic condition. The substrates bearing different substituents were tolerated well and afforded the corresponding products with moderate to good yields.

Key words: air, tertiary amines, C—N bond cleavage, methylene-bridged compounds