One-Step Synthesis of Isoquinolinone Compounds

doi:10.6023/cjoc201705038

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (11): 2972-2977.DOI: 10.6023/cjoc201705038 Previous Articles Next Articles

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一步法合成异喹啉酮类化合物

王保取, 孔令斌, 罗琴, 林军, 严胜骄

云南大学化学科学与工程学院教育部自然资源药物化学重点实验室昆明 650091

收稿日期:2017-05-27 修回日期:2017-07-06 发布日期:2017-07-18
通讯作者: 林军, 严胜骄 E-mail:linjun@ynu.edu.cn;yansj@ynu.edu.cn
基金资助:
国家自然科学基金（Nos.21362042，21662042，U1202221，21262042）、云南省自然科学基金（No.2017FA003）、云南省后备人才（No.2012HB001）、云南大学东陆学者及云南大学青年英才计划（No.XT412003）资助项目.

One-Step Synthesis of Isoquinolinone Compounds

Wang Baoqu, Kong Lingbin, Luo Qin, Lin Jun, Yan Shengjiao

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091

Received:2017-05-27 Revised:2017-07-06 Published:2017-07-18
Contact: 10.6023/cjoc201705038 E-mail:linjun@ynu.edu.cn;yansj@ynu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21362042, 21662042, U1202221, 21262042), the Natural Science Foundation of Yunnan Province (No. 2017FA003), the Talent Found in Yunnan Province (No. 2012HB001), the Donglu Scholar of Yunnan University and the Excellent Young Talents in Yunnan University (No. XT412003).

1. One-Step Synthesis of Isoquinolinone Compounds.PDF(7915KB)

Abstract

A concise and efficiently route for the synthesis of isoquinolinones via one-step reaction of nitro substituted methyl 2-fluorobenzoate 1 and heterocyclic ketone aminals (HKAs, 2) in 1,4-dioxane catalyzed by Cs₂CO₃ under reflux conditions has been developed. Isoquinolinones 3 were obtained by one-step strategy. This protocol possesses some advantages including readily available starting materials, simple operation and concise synthetic route and so on.

Key words: environment friendly, atom economy, heterocyclic ketone aminals, isoquinolinones

Cite this article

Wang Baoqu, Kong Lingbin, Luo Qin, Lin Jun, Yan Shengjiao. One-Step Synthesis of Isoquinolinone Compounds[J]. Chin. J. Org. Chem., 2017, 37(11): 2972-2977.

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一步法合成异喹啉酮类化合物

One-Step Synthesis of Isoquinolinone Compounds

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