Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3248-3256.DOI: 10.6023/cjoc201710037 Previous Articles     Next Articles



蒋友好a, 陆国林b, 彭文a   

  1. a 上海中医药大学附属普陀医院 上海 200062;
    b 中国科学院上海有机化学研究所 上海 200032
  • 收稿日期:2017-10-31 修回日期:2017-11-09 发布日期:2017-11-15
  • 通讯作者: 彭文
  • 基金资助:

Synthesis of Phenoxyallene-Based Amphiphilic Block Copolymer

Jiang Youhaoa, Lu Guolinb, Peng Wena   

  1. a Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062;
    b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2017-10-31 Revised:2017-11-09 Published:2017-11-15
  • Contact: 10.6023/cjoc201710037
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21674124).

An amphiphilic triblock copolymer comprising double-bond-containing poly(phenoxyallene) (PPOA) was synthesized by a combination of conventional free radical polymerization and atom transfer radical polymerization (ATRP) via the site transformation strategy. A new bifunctional initiator containing azo and ATRP initiating groups was prepared and used for conventional free radical homopolymerization of phenoxyallene (POA) to afford a PPOA-based macroinitiator bearing ATRP initiating groups. Subsequent ATRP of hydrophilic monomer, 2-((diethylamino)ethyl methacrylate) (DEAEMA), initiated by PPOA-based macroinitiator afforded PDEAEMA-b-PPOA-b-PDEAEMA triblock copolymer. This triblock copolymer can self-assemble into micelles, and critical micelle concentration (cmc) of PDEAEMA-b-PPOA-b-PDEAEMA amphiphilic triblock copolymer in aqueous solution was determined by fluorescence probe technique. The dependence of cmc on pH and ion strength was also investigated.

Key words: polyallene, block copolymer, bifunctional initiator, ATRP