Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 328-338.DOI: 10.6023/cjoc201806003 Previous Articles     Next Articles



张京星a, 姚婷婷a, 刘晶a, 李花月a,b, 李文利a,b   

  1. a 中国海洋大学医药学院 教育部海洋药物重点实验室 青岛 266003;
    b 青岛海洋科学与技术国家实验室 海洋生物学与生物技术功能实验室 青岛 266237
  • 收稿日期:2018-06-01 修回日期:2018-09-10 发布日期:2018-09-18
  • 通讯作者: 李文利
  • 基金资助:


Recent Advances in Cyclodipeptide Synthases-Dependent Biosynthetic Pathway

Zhang Jingxinga, Yao Tingtinga, Liu Jinga, Li Huayuea,b, Li Wenlia,b   

  1. a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003;
    b Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237
  • Received:2018-06-01 Revised:2018-09-10 Published:2018-09-18
  • Contact: 10.6023/cjoc201806003
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 31171201, 81561148012, 31570032).

Diketopiperazines (DKPs) are derivatives of cyclodipeptides resulted from the condensation of two α-amino acids. The conformationally constrained six-membered ring makes DKP an attractive pharmacophore in medicinal chemistry, exhibiting a wide range of bioactivities. Recently, there has been increased interests in synthesizing DKPs and biosynthesis is an effective pathway to broaden their structural diversity. Different from non-ribosomal peptide synthetases (NRPSs)-dependent pathways, cyclodipeptide synthases (CDPSs) use aminoacyl-tRNAs (aa-tRNAs) as substrates and the resulting cyclodipeptides are further modified by associated tailoring enzymes to yield the final products. To date, six CDPS-dependent pathways for synthesizing DKPs compounds have been reported. A brief overview of recent progresses on CDPS-dependent DKPs biosynthetic pathway is provided.

Key words: diketopiperazines, non-ribosomal peptide synthetases, cyclodipeptide synthases, biosynthetic pathway