Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (4): 1064-1069.DOI: 10.6023/cjoc201809003 Previous Articles     Next Articles

Special Issue: 元素有机化学合辑2018-2019



张明千, 刘斌凯, 雷强, 颜景东, 赵中玉, 龙跃   

  1. 郑州大学化学与分子工程学院 郑州 450001
  • 收稿日期:2018-09-03 修回日期:2018-10-27 发布日期:2018-12-21
  • 通讯作者: 龙跃
  • 基金资助:


Synthesis and Biological Activities of 1,3,4-Thiadiazole Triazene Compound

Zhang Mingqian, Liu Binkai, Lei Qiang, Yan Jingdong, Zhao Zhongyu, Long Yue   

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
  • Received:2018-09-03 Revised:2018-10-27 Published:2018-12-21
  • Contact: 10.6023/cjoc201809003
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.J1210060),the Science and Technology Planning Project of Henan Province (No.0624420031) and the Basic Research Development Program of Henan Province (No.022463001).

Using the splicing principle of combining the pharmacological group triazene with 1,3,4-thiadiazole, 15 unreported 1,3,4-thiadiazole triazene derivatives were synthesized. The structures of the compounds were determined by nucleated magnetic resonance spectroscopy (NMR), infrared spectroscopy (IR) and high-resolution mass spectrometry (HRMS). By using the typical triazene drug dacarbazine (DTIC) and drug 5-fluorouracil (5-FU) as a reference, the activity detections of human esop-hageal cancer cells (EC109), human gastric cancer cells (MGC803), and human prostate cancer cells (PC-3) were carried out. The results showed that some compounds inhibited human gastric cancer cells (MGC803) more strongly than dacarbazine (DTIC), and the IC50 values of compounds 2-(3-methyanilino)-5-[4-(3,3-dimethyltriazol-1-yl) phenyl]-1,3,4-thiadiazole (8c), 2-(2-methoxyanilino)-5-[4-(3,3-dimethyltriazol-1-yl) phenyl]-1,3,4-thiadiazole (8f), and 2-(3,4-dichloroanilino)-5-[4-(3,3-di-methyltriazol-1-yl) phenyl]-1,3,4-thiadiazole (8l) were lower than those of 5-fluorouracil with 5.3, 6.5 and 6.3 μmol/L, respec-tively. Some compounds inhibited human prostate cancer cells (PC-3) more strongly than dacarbazine (DTIC), and the IC50 value of 8l is lower than that of 5-fluorouracil with 13.5 μmol/L.

Key words: triazene, 1,3,4-thiadiazole, human esophageal cancer cells, human gastric cancer cells, human prostate cancer cells