Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3223-3229.DOI: 10.6023/cjoc201904051 Previous Articles     Next Articles

三乙胺促进的α-卤代酮C-C键断裂:合成α-乙酰氧基芳基酮

王毛锐, 吴雨峥, 姚健, 邓黎, 潘英明, 黄克斌*(), 唐海涛*()   

  1. 广西师范大学化学与药学院 药物资源化学与分子工程国家重点实验室 广西桂林 541004
  • 收稿日期:2019-04-22 出版日期:2019-11-25 发布日期:2019-07-03
  • 通讯作者: 黄克斌,唐海涛 E-mail:kbhuang@mailbox.gxnu.edu.cn;httang@gxnu.edu.cn
  • 基金资助:
    国家自然科学基金(21362002);中国广西省八桂学者(2016A13)

Triethylamine Promoted the C-C Bond Cleavage of α-Halo Ketones: α-Acetoxyaryl Ketone Synthesis

Wang Maorui, Wu Yuzheng, Yao Jian, Deng Li, Pan Yingming, Huang Kebin*(), Tang Haitao*()   

  1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, Guangxi 541004
  • Received:2019-04-22 Online:2019-11-25 Published:2019-07-03
  • Contact: Huang Kebin,Tang Haitao E-mail:kbhuang@mailbox.gxnu.edu.cn;httang@gxnu.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(21362002);the Bagui Scholar Program of Guangxi Province of China(2016A13)

The cleavage of C-C bonds is a key method for synthesis of useful intermediates. A novel amine-promoted C-C bond cleavage of α-halo ketones was reported. Oxidant-free and metal-free conditions are the striking features of the protocol. In this simple method, a variety of α-acetoxyaryl ketone compounds were prepared from commercially available α-halo ketones in good to excellent yields.

Key words: cleavage of C-C bonds, α-halo ketones, oxidant-free and metal-free, α-acetoxyaryl ketone