Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (05): 667-673 .DOI: 10.6023/A1106233 Previous Articles    

Full Papers

乌苏酸/DPPC 混合单层膜相互作用的研究

王夫雨, 孙润广, 陈莹莹, 王小梅, 柴政   

  1. 陕西师范大学 物理学与信息技术学院生物物理与生物医学工程研究室 西安 710062
  • 投稿日期:2011-06-23 修回日期:2011-10-17 发布日期:2011-11-22
  • 通讯作者: 孙润广
  • 基金资助:

    国家自然科学基金(No. 20772077)和教育部高等学校博士学科点专项科研基金(No. 200807180001)资助项目.

Monolayer Study on the Interaction between Ursolic Acid and DPPC

Wang Fuyu, Sun Runguang, Chen Yingying, Wang Xiaomei, Chai Zheng   

  1. Laboratory of Biophysics and Biomedical Engineering, College of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062
  • Received:2011-06-23 Revised:2011-10-17 Published:2011-11-22
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20772077) and Doctoral Fund of Ministry of Education of China (No. 200807180001).

In this work, the interaction of urasolic acid (UA, a natural pentacyclic triterpene) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, an important phospholipid in cell membrane) was investigated. The mean and excess surface area per molecule, elastic modulus, excess Gibbs energy, and interaction parameter of mixed monolayer were studied based on the surface pressure-area isotherms. The authors found that, as well as cholesterol, UA can induce the DPPC molecules on the monolayer condensation. The stability, compressibility and thermodynamic characteristics of binary system of UA and DPPC are connected with the surface pressure and the mole faction of UA. The AFM experiment supported the conclusion effectively.

Key words: urasolic acid, monolayer, elastic modulus, excess Gibbs energy, atomic force microscopy