Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (06): 714-720.DOI: 10.6023/A1107051 Previous Articles     Next Articles

Special Topic


韦俏娜, 马林, 黄爱民, 杨华, 龚珠萍, 强盼盼, 张丽   

  1. 广西大学化学化工学院 南宁 530004
  • 投稿日期:2011-07-05 修回日期:2011-11-16 发布日期:2011-12-09
  • 通讯作者: 马林
  • 基金资助:

    国家自然科学基金(No. 21063002), 广西自然科学基金(No. 2011jjC30004)和广西研究生创新计划(No. 105931003028)资助项目.

Controlled Drug Release from Silk Fibroin Films Treated with Methanol-water Mixtures

Wei Qiaona, Ma Lin, Huang Aimin, Yang Hua, Gong Zhuping, Qiang Panpan, Zhang Li   

  1. College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004
  • Received:2011-07-05 Revised:2011-11-16 Published:2011-12-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21063002), Natural Science Foundation of Guangxi Province (No. 2011jjC30004) and Post-graduate Innovation Program of Guangxi Province (No. 105931003028).

Silk fibroin (SF) films were prepared using a casting method and the structural change owing to treatment with methanol-water mixtures of different concentrations was investigated by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The results were used to reveal the influence of structure on the release dynamics of Rhodamine B, a model compound loaded in the SF matrix. In methanol concentration ranging from 50% to 90%, the content of silk Ⅱ crystalline structure, constituted by β-sheet, first increased and then decreased with increasing methanol concentration in the mixtures, reaching a maximum around 80%. It was found that Rhodamine B released from the SF film via Fickian mechanism, of which the diffusional exponent increased with increasing β-sheet content in the matrix, suggesting that the silk Ⅱ crystal could be used as natural regulator for drug release from SF material.

Key words: silk fibroin, controlled release, structural change