Acta Chimica Sinica ›› 2022, Vol. 80 ›› Issue (3): 255-258.DOI: 10.6023/A22010002 Previous Articles Next Articles
Special Issue: 中国科学院青年创新促进会合辑
Communication
投稿日期:
2022-01-01
发布日期:
2022-02-11
通讯作者:
王丽佳, 唐勇
作者简介:
基金资助:
Long Zhenga, Lijia Wanga,b,c(), Yong Tanga()
Received:
2022-01-01
Published:
2022-02-11
Contact:
Lijia Wang, Yong Tang
About author:
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Long Zheng, Lijia Wang, Yong Tang. Intramolecular Ring-opening of Indole-cyclopropanes※[J]. Acta Chimica Sinica, 2022, 80(3): 255-258.
Entry | Lewis acid | Solvent | Time/h | Conv./% | Yieldb/% |
---|---|---|---|---|---|
1 | Cu(OTf)2 | DCM | 24 | 0 | — |
2 | Zn(OTf)2 | DCM | 24 | 0 | — |
3 | Fe(OTf)3 | DCM | 24 | 0 | — |
4 | La(OTf)3 | DCM | 24 | 0 | — |
5 | YbOTf)3 | DCM | 24 | 0 | — |
6 | Ga(OTf)3 | DCM | 24 | 15 | 15 |
7 | Sc(OTf)3 | DCM | 24 | 29 | 11 |
8 | In(OTf)3 | DCM | 24 | 76 | 66 |
9 | InCl3 | DCM | 24 | 8 | 7 |
10 | InBr3 | DCM | 24 | 38 | 34 |
11 | In(NTf2)3 | DCM | 24 | 86 | 82(80) c |
12 | In(NTf2)3 | THF | 72 | — | — |
13 | In(NTf2)3 | Toluene | 11 | 100 | 99(90) c |
14 | In(NTf2)3 | PhCl | 7 | 100 | 99(90) c |
Entry | Lewis acid | Solvent | Time/h | Conv./% | Yieldb/% |
---|---|---|---|---|---|
1 | Cu(OTf)2 | DCM | 24 | 0 | — |
2 | Zn(OTf)2 | DCM | 24 | 0 | — |
3 | Fe(OTf)3 | DCM | 24 | 0 | — |
4 | La(OTf)3 | DCM | 24 | 0 | — |
5 | YbOTf)3 | DCM | 24 | 0 | — |
6 | Ga(OTf)3 | DCM | 24 | 15 | 15 |
7 | Sc(OTf)3 | DCM | 24 | 29 | 11 |
8 | In(OTf)3 | DCM | 24 | 76 | 66 |
9 | InCl3 | DCM | 24 | 8 | 7 |
10 | InBr3 | DCM | 24 | 38 | 34 |
11 | In(NTf2)3 | DCM | 24 | 86 | 82(80) c |
12 | In(NTf2)3 | THF | 72 | — | — |
13 | In(NTf2)3 | Toluene | 11 | 100 | 99(90) c |
14 | In(NTf2)3 | PhCl | 7 | 100 | 99(90) c |
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