Acta Chimica Sinica ›› 1954, Vol. 20 ›› Issue (1): 84-91. Previous Articles     Next Articles

嘧啶的研究:4-甲基-5-乙基-2, 6-二甲氧基嘧啶的分子重排作用

纪育澧, 凌育宸   

  1. 中央卫生研究院药物学系
  • 投稿日期:1954-03-19 发布日期:2013-06-04

PYRIMIDINE RESEARCH:THE MOLECULAR REARRANGEMENT OF 4-METHYL-5-ETHYL-2, 6-DIMETHOXY-PYRIMIDINE

CHI YUOH-FONG(YUOH-FONG CHI), LING YUOH-CHERN   

  1. Deportment of Pharmaceutics, Central Ruearch Institute of Health
  • Received:1954-03-19 Published:2013-06-04

4-Methyl-6-ethyl-2-thiouracil, m.p. 211°,was prepared according to the directions of Johnson and Baily. 4-Methyl-6-ethyl-uracil, m. p.236°,was formed in a 81% yield from 4-methyl-6-ethyl-2-thiouracil by boiling the latter with an aqueous solution of monochloroacetic acid. 4-Methyl-6-ethyl-uracil reacted with phosphorous oxychloride and phosphorous pentachloride, giving 4-methyl-6-ethyl-2,6-dichloropy-rimidine in a 79% yield.