share
Acta Chimica Sinica ›› 1956, Vol. 22 ›› Issue (1): 24-32. Previous Articles Next Articles
高怡生, 潘百川, 陆顺兴, 徐修容, 陈志豪
投稿日期:
发布日期:
KAO YEE-SHENG, PAN PEI-CHUAN, LOH SHUEN-HSING, HSU HSIU-YONG, CHEN CHI-HAO
Received:
Published:
Share
The synthesis of dl-threo-3-chloro-3-phenyl-2-aminopropanol hydrochloride (Ⅳ), a useful intermediate for the preparation of racemic chloramphenicol[4], has been achieved by treating 1-phenyl-2-amino-3-ethoxypropanol hydrochloride (Ⅴ), m.p. 119-120°, with concentrated hydrochloric acid in sealed tube; the ethoxy group being converted to hydroxyl, and the replacement of secondary hydroxyl by chlorine having also taken place. The compound Ⅴ was in turn prepared by a 3-step synthesis starting with ethyl α-benzoyl-β-ethoxyacrylate (Ⅵ).
KAO YEE-SHENG, PAN PEI-CHUAN, LOH SHUEN-HSING, HSU HSIU-YONG, CHEN CHI-HAO. SYNTHESIS OF A USEFUL INTERMEDIATE FOR THE PREPARATION OF CHLORAMPHENICOL AND SOME RELATED CONDENSATIONS[J]. Acta Chimica Sinica, 1956, 22(1): 24-32.
Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks