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Acta Chimica Sinica ›› 1956, Vol. 22 ›› Issue (3): 177-183. Previous Articles     Next Articles

嘧啶的研究：2-酮-1,2,3,4-四氫化嘧啶的合成：乙醯基丙酮與醛類對尿素的反應

紀育灃, 凌育宸   

  1. 中央衛生研究院藥物学系, 中國科学院化学研究所
  • 投稿日期:1956-02-21 发布日期:2013-06-04

PYRIMIDINE RESEARCH： SYNTHESIS OF 2-KETO-1,2,3,4-TETRAHYDRO-PYRIMIDINES.THE REACTION OF ACETYLACETONE AND ALDEHYDE ON UREA

CHI YUOH-FONG, LING YUOH-CHERN   

  1. Department of Therapeutics, Central Institute of Health;Institute of Chemistry, Academia Sinica
  • Received:1956-02-21 Published:2013-06-04

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The condensation of urea, acetyl-acetone and various aldehydes gave 2-keto-4-R-5-acetyl-6-methyl-1,2,3,4-te:rahydro-pytimidine (I), following the course of the reaction according to Biginelli condensation, which was reinvestigated by Johnson and his co-workers.