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Acta Chimica Sinica ›› 1958, Vol. 24 ›› Issue (1): 105-111. Previous Articles     Next Articles

氯霉素相似化合物的合成——Ⅲ. 1-(隣羟-对硝基苯)-2-二氯乙酰胺基乙醇及1-(隣羟甲基-对硝基苯)-2-二氯乙酰胺基乙醇

高怡生, 徐修容   

  1. 中国科学院药物研究所 上海
  • 投稿日期:1957-09-09 发布日期:2013-06-03

SYNTHESIS OF COMPOUNDS RELATED TO CHLORAMPHENICOL Ⅲ. I-(o-HYDROXY-p-NITROPHENYL)-2-DICHLOROACETAMIDO-ETHANOL. AND 1-(o-HYDROXYMETHYL-p-NITROPHENYL)-2-DICHLOROACETAMIDO-ETHANOL

KAO YEE-SHENG, HSU HSIU-YUNG   

  1. Institute of Materia Medica, Acudemia Sinica
  • Received:1957-09-09 Published:2013-06-03

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A mongest hundreds of analogues of chloramphenicol, which have so far been synthesized and studied for their relationships between chemical constitution and biological action, one concept is to eurtail the hydroxymethyl group in the structure of chloramphenicol to form a simpler compound, 1-(p-nitrophenyl)-2-dichloroacetamido-ethanol(Ⅱ), in which one asymmetric carbon being eliminated.