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Acta Chimica Sinica ›› 1962, Vol. 28 ›› Issue (6): 372-378. Previous Articles     Next Articles

氯霉素相似化合物的合成Ⅳ.3-(邻羥基-对硝基苯基)-2-二氯乙酰氨基-丙醇

高怡生, 潘百川   

  1. 中国科学院药物研究所
  • 投稿日期:1962-04-09 发布日期:2013-06-03

SYNTHESIS OF COMPOUNDS RELATED TO CHLORAMPHENICOL Ⅳ. 3-(o-HYDROXY-p-NITROPHENYL)-2-DICHLOROACETAMIDO-PROPANOL

KAO YEE-SHENG, PAN PEI-CHUAN   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1962-04-09 Published:2013-06-03

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For further studying the relationships between antibacterial action and hydrogen bonding structure in compounds related to chloramphenicol, the authors have synthesized 3-(o-hydroxy-p-nitrophenyl)-2-dichloroacetamido-propanol(Ⅴ), in which hydrogen bonding possibility was eliminated by converting the carbonyl group into methylene group.