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Acta Chimica Sinica ›› 1964, Vol. 30 ›› Issue (2): 146-152. Previous Articles     Next Articles

降压药物的合成研究Ⅱ.若干氮七环基和氮八环基化合物的合成

白东鲁, 嵇汝运   

  1. 中国科学院药物研究所
  • 投稿日期:1963-05-13 发布日期:2013-06-03

SYNTHETIC STUDIES ON HYPOTENSIVE AGENTS Ⅱ. THE PREPARATION OF SOME COMPOUNDS CARRYING HEXAMETHY-LENIMINO AND HEPTAMETHYLENIMINO GROUPS

BAI DONG-LU, KYI ZU-YOONG   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1963-05-13 Published:2013-06-03

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Bretylium (Ⅰ) and guanethidine (Ⅱ) were reported to have protracted antihypertensive properties with the capacity to block the transmission at peripheral adrenergic nerve terminals.It appears interesting to study the relationship between their chemical constitutions and pharmacological activities.The present work deals with the structural modification of Ⅰ and Ⅱ.