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Acta Chimica Sinica ›› 1978, Vol. 36 ›› Issue (1): 23-34. Previous Articles     Next Articles

抗肿瘤及抗病毒药物的研究——Ⅳ.α-酮醛与肼、羟胺及芳胺缩合化合物的合成

吴元鎏, 王琳, 蒋湘君, 黄量   

  1. 中国医学科学院药物研究所
  • 投稿日期:1976-04-26 发布日期:2013-06-03

STUDIES ON ANTITUMOUR AND ANTIVIRAL COMPOUNDS——Ⅳ.THE SYNTHESES OF CONDENSATION PRODUCTS OF HYDRAZINES, HYDROXYLAMINES AND AROMATIC AMINES WITH SOME α-GLYOXALS

WU YUAN-LIU, WANG LIN, JIANG XIANG-JUN, HUANG LIANG   

  1. Institute of Materia Medica, Chinese Academy of Medical Sciences
  • Received:1976-04-26 Published:2013-06-03

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It has been known that some α-glyoaals exhibit marked aniiviral aotivity in embryonated eggs but frequently lose their activity in animal tests. The inactivity in animal tests may be explained by the high chemical resotivities so that they are rapidly destroyed in the complex animal system before reaching the target site.