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Acta Chimica Sinica ›› 1978, Vol. 36 ›› Issue (2): 154-158. Previous Articles     Next Articles

外消旋前列腺素E1和F1α甲酯的合成

前列腺素研究小组   

  1. 中国科学院上海有机化学研究所, 上海第十二制药厂
  • 投稿日期:1977-03-07 发布日期:2013-06-03

SYNTHESIS OF THE RACEMIC PROSTAGLANDIN E1 AND F1αMETHYL ESTERS

PROSTAGLANDIN RESEARCH GROUP   

  1. Shanghai Institute of Organic Chemistry, Academia Sinica, Shanghai No.12. Pharmaceutical Works
  • Received:1977-03-07 Published:2013-06-03

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Prostaglandin E1 methyl ester is synthesized from the common key intermediate Ⅰ with conjugated addition of Grignard reagent as a key step.The intermediate Ⅳ is stereoselectively reduced with sodium borohydride to give Ⅵ, which is converted to prostaglandin F1α methyl ester.