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Acta Chimica Sinica ›› 1980, Vol. 38 ›› Issue (6): 606-609. Previous Articles     Next Articles

β,γ-不饱和仲烃基乙酰乙酸乙酯的皂化及芳樟醇衍生物的合成

郭文松1, 蔡昆2, 张永敏3   

  1. 1. 贵州省化工研究所 贵阳;
    2. 新乡师范学院化学系 河南;
    3. 杭州大学化学系
  • 投稿日期:1978-12-21 发布日期:2013-06-03

SAPONIFICATION OF β, γ-UNSATURATED SEC-ALKYL ACETOACETIC ACID ESTERS AND THE SYNTHESIS OF LINALOOL DERIVATIVES

GUO WEN-SONG1, CAI KUN2, ZHANG YONG-MIN3   

  1. 1. Guizhou Institute of Chemical Engineering, Guiyang;
    2. Department of Chemistry, Xingxiang Normal College, Henan;
    3. Department of Chemistry, Hangzhou University
  • Received:1978-12-21 Published:2013-06-03

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Acoording to the Grignard's method modified by Normant,the corresponding vinyl magnesium bromide was prepared by treating the 2,2-dimethyl vinyl bromide (isobutenyl bromide) with metallic magnesium in tetrahydrofuran.With this Grignard-Normant reagent and alkylidene aoetoacetio aoid esters (at the temperature of -10 to -5℃),we had obtained a series of unsaturated sec-alkyl acetoacetio acid esters whioh were then saponified to give 4-alkyl-6-methyl-5-heptene-2-ones.5-substituted Tinalools were thus obtained by the reactions of these heptenones with vinyl magnesium bromide in fair yield.