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Acta Chimica Sinica ›› 1982, Vol. 40 ›› Issue (7): 648-656. Previous Articles     Next Articles

对称二酮类化合物的徽生物不对称还原——Ⅰ.2-烷基-2-(3’-羰基丁基)-1,3-环戊二酮的不对称还原

周维善1, 黄大中1, 董纪昌2, 王锺麒1   

  1. 1. 中国科学院上海有机化学研究所;
    2. 上海第一医学院药学系
  • 投稿日期:1980-12-31 发布日期:2013-06-03
  • 通讯作者: 周维善

ASYMMETRICAL REDUCTION OF THE SYMMETRICAL DIKETONES BY MICRO-ORGANISM——Ⅰ. ASYMMETRICAL REDUCTION OF 2-ALKYL-2-(3’-OXOBUTYL)-1, 3-CYCLOPENTANEDIONE

ZHOU WEI-SHAN1, HUANG DA-ZHONG1, DONG QI-CHANG2, WANG ZHONG-QI1   

  1. Shanghai Institute of Organic Chemistry, Academia Sinica
  • Received:1980-12-31 Published:2013-06-03

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The optically active intermediates 6(R=CH3, C2H5) for total syntheses of steroidal oral contraceptives was prepared from symmetrical diketones 2 (R=CH3,C2H5 by microbial asymmetrical reduction.Thus 2a and 2b were cultivated with Saccharomyces cerevisirie (2.346) to give optically active products 6a and 6b in 73% and 71% yields respectively.