Acta Chimica Sinica ›› 1989, Vol. 47 ›› Issue (8): 771-774. Previous Articles     Next Articles

Original Articles

青蒿素及其一类物的结构和合成 XXIII: 脱氧青蒿素碱降解产物内酯构型的测定

许杏祥;朱杰;张联;周维善   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1989-08-15

Studies on the structure and syntheses of arteannuin and related compounds XXIII: The lactone configuration of the deoxyarteannuin degradation product

XU XINGXIANG;ZHU JIE;ZHANG LIAN;ZHOU WEISHAN   

  • Published:1989-08-15

An empirical rule between the lactone configuration and the chem. shift of a-position hydrogen of lactone carbonyl (i.e. 11-Ha) in a series of dihydroarteannuin B compounds was proposed. On the basis of this rule, the lactone configuration of deoxyarteannuin degradation product I was assigned as b-cis, which was further proved by its synthesis. The reaction mechanism was also discussed.

Key words: LACTONES, CHEMICAL SHIFT, ARTEANNUIN, EPOXIDE, CONFIGURATION, DEGRADATION PRODUCTS

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