Acta Chimica Sinica ›› 1990, Vol. 48 ›› Issue (2): 168-173. Previous Articles     Next Articles

Original Articles

(+)-樟脑缩苄胺体系的不对称羰基加成反应

刘桂兰;邓金根;蒋耀忠   

  1. 中国科学院成都有机化学研究所
  • 发布日期:1990-02-15

Asymmetric carbonyl addition reaction of (+)-camphor imine derived from benzylamine

LIU GUILAN;DENG JINGEN;JIANG YAOZHONG   

  • Published:1990-02-15

The 1,2-substituted 2-aminoethanol derivatives I (R = Ph, 4-MeOC6H4, 3,4-(MeO)C6H7; R' = H, Me, Ph) were synthesized from the asym. addition of (+)-camphor imine II derived from benzylamine to a variety of aldehydes or ketones RCOR'. The diastereoselectivities ranging from 16-70% were determine by NMR spectra of addition products III.

Key words: NMR SPECTROMETRY, CARBONYL SYNTHESIS, ADDITION REACTION, KETONE, CAMPHOR, DIASTEROISOMERISM, EXTERNAL PHASE BOUNDARY FILM, AMINO ETHANOL P, BENZENEMETHANAMINIUM

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