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Acta Chimica Sinica ›› 1993, Vol. 51 ›› Issue (9): 933-936. Previous Articles
Original Articles
王志光;马维勇;张椿年
发布日期:
WANG ZHIGUANG;MA WEIYONG;ZHANG CHUNNIAN
Published:
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Reaction of 4-bromo-4-deoxy-4'-demethylepipodophyllotoxin with selenourea followed by displacement with active alkyl halides in the presence of Et3N gave 4-alkylselenyl-4-deoxy-4'-demethylepipodophyllotoxins. Six compounds containing Se, e.g. I, showed marked antitumor activities.
Key words: TRIETHYL AMINE P, SELENIUM COMPOUNDS, PODOPHYLLOTOXIN, ANTITUMOR DRUGS, SELENOUREA
CLC Number:
R914
WANG ZHIGUANG;MA WEIYONG;ZHANG CHUNNIAN. Synthesis and antitumor activities of 4-alkylselenyl-4-deoxy-4'- demethylepipodophyliotoxin[J]. Acta Chimica Sinica, 1993, 51(9): 933-936.
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