Acta Chimica Sinica ›› 1993, Vol. 51 ›› Issue (9): 933-936. Previous Articles    

Original Articles

4-烷硒基-4-脱氧-4'-去甲表鬼臼毒素衍生物的合成和抗肿瘤活性

王志光;马维勇;张椿年   

  1. 国家医药管理局上海医药工业研究院
  • 发布日期:1993-09-15

Synthesis and antitumor activities of 4-alkylselenyl-4-deoxy-4'- demethylepipodophyliotoxin

WANG ZHIGUANG;MA WEIYONG;ZHANG CHUNNIAN   

  • Published:1993-09-15

Reaction of 4-bromo-4-deoxy-4'-demethylepipodophyllotoxin with selenourea followed by displacement with active alkyl halides in the presence of Et3N gave 4-alkylselenyl-4-deoxy-4'-demethylepipodophyllotoxins. Six compounds containing Se, e.g. I, showed marked antitumor activities.

Key words: TRIETHYL AMINE P, SELENIUM COMPOUNDS, PODOPHYLLOTOXIN, ANTITUMOR DRUGS, SELENOUREA

CLC Number: