Microcarpacin (1), a new adjacent bis-tetrahydrofuranyl annonaceous acetogenin was isolated from the seeds of Uvaria microcarpa Champ. ex Benth. The structure of 1 is elucidated based on spectroscopic methods and the existence of four hydroxys is confirmed by the acetylation of the title compound. Microcarpacin is the first example with a hydroxyl group at 33-C among the known annonaceous acetogenins. In addition, two known 24-C epimeric acetogenins, Narumicins I (2) and Narumicins II (3) were also isolated from the same plant source. The pure compounds 2 and 3 were obtained for the first time by careful HPLC preparation and the spectral data of the corresponding compound are also reported in this paper.

Key words: CHEMICAL COMPOSITION, TETRAHYDROFURAN P