Acta Chimica Sinica ›› 1998, Vol. 56 ›› Issue (4): 385-390. Previous Articles     Next Articles

Original Articles

催化2-(对甲氧苯氧基)-四氢吡喃缩醛键水解的抗体研究

杨炳辉;宋建峰;赵菁菁;孔黄宽;季永镛;叶敏   

  1. 中国科学院上海有机化学研究所;中国科学院生命有机化学国家重点实验室;中国科学院上海细胞生物学研究所
  • 发布日期:1998-04-15

Studies on antibody catalysis of acetal bond hydrolysis in 2-(p-methoxy-phenoxy)-tetrahydropyran

YANG BINGHUI;SONG JIANFENG;ZHAO JINGJING;KONG HUANGKUAN;JI YONGYONG;YE MIN   

  • Published:1998-04-15

A monoclonal antibody (1D1) is raised against the hapten (2), a transition state analog for the hydrolysis of 2-(p-methoxy-phenoxy)-tetrahydropyran(1), by immunization and hybridoma techniques and possesses a catalytic capacity for hydrolysis of compound (1) in pH=5.60 at 37℃ folds rate acceleration.

Key words: HYDROLYSIS, ANTIGENS, PYRANE P, ACETAL

CLC Number: