In order to better understand the dependence of bioactivities on the structures of the fluorine-containing new pesticidal compounds and to build up significant structure-bioactivity models, the relationships between the structures and two different kinds of bioactivities of 33 fluorine-containing compounds have been investigated by classical QSAR methods. The obtained bioactive model for cucumber disease has a good capability for the explanation and prediction. Based on this model some new active structures were designed. However, no significant model was obtained for the bioactive data of water-melon disease. This work resulted in a typical QSAR studying scheme in which the cluster analysis is applied, followed by the multivariate statistical methods for a deeper investigation.

Key words: ORGANOFLUORINE INSECTICIDES, PESTICIDES, BIOLOGICAL ACTIVITY, STRUCTURE AND PROPERTY CORRELATION, QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP, CHEMICAL STRUCTURE