Studies on the chiral selectivity of transmembrane transport of  the pt(Ⅱ)complexeswith 1,2--diaminocyclohexane as carrier ligand  into human erythrocytes

Acta Chimica Sinica ›› 1999, Vol. 57 ›› Issue (7): 659-666. Previous Articles Next Articles

Original Articles

人红细胞摄取环己二胺合铂(Ⅱ)配合物的手性选择性研究

高愈希;李荣昌;吴刚;卢景芬;王夔

北京医科大学生物无机及无机药物化学系;北京医科大学天然药物与仿生药物国家重点实.北京(100083)

发布日期:1999-07-15

Studies on the chiral selectivity of transmembrane transport of the pt(Ⅱ)complexeswith 1,2--diaminocyclohexane as carrier ligand into human erythrocytes

Gao Yuxi;Li Rongchang;Wu Gang;Lu Jingfen;Wang Kui

Beijing Med Univ., Laboratory of Natural and Bionic Drugs.Beijing (100083)

Published:1999-07-15

Abstract

Six Pt(Ⅱ) complexes with chital 1,2 --diaminocyclohexane as carrier ligand were synthesized, their compositions and strctures were characterized by elemental analysis,IR spectroscopy and molecular modeling. The first -order rate constants for the transmembrane transport of the complxes into human erythrocytes were detemined and the mechanism was studied on the basis of the interactions of these complexes with cellular membranes and liposome by ESR,fluorescence technique, mercapto measurement and gelchromatography. The results show that the transmembrane transport of the complexes studied exhibited a chiral selectivity, and the selectivity is mainly due to chiral recognition of membrane phospholipid with the chiral complexes.

Key words: ERYTHROCYTES, PLATINUM COMPLEX, ELEMENTAL ANALYSIS, INFRARED SPECTROPHOTOMETRY, LIPOSOME, UPTAKE

CLC Number:

O611.662

Cite this article

Gao Yuxi;Li Rongchang;Wu Gang;Lu Jingfen;Wang Kui. Studies on the chiral selectivity of transmembrane transport of the pt(Ⅱ)complexeswith 1,2--diaminocyclohexane as carrier ligand into human erythrocytes[J]. Acta Chimica Sinica, 1999, 57(7): 659-666.

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人红细胞摄取环己二胺合铂(Ⅱ)配合物的手性选择性研究

Studies on the chiral selectivity of transmembrane transport of the pt(Ⅱ)complexeswith 1,2--diaminocyclohexane as carrier ligand into human erythrocytes

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