Allyl as  aprotective group for the synthesis of modified oligonucleotides

Acta Chimica Sinica ›› 2001, Vol. 59 ›› Issue (10): 1691-1696. Previous Articles Next Articles

Original Articles

烯丙基作为保护基在修饰寡核苷酸合成中的应用

周英;张亮仁;张礼和

北京大学天然药物及仿生药物国家重点实验室

发布日期:2001-10-15

Allyl as aprotective group for the synthesis of modified oligonucleotides

Zhou Ying;Zhang Liangren;Zhang Lihe

Published:2001-10-15

Abstract

The possibility of allyl as protective group of the hydroxyls in nucleosides for the synthesis of oligonucleotides was studied. Allyl group could be removed by PdCl2 under mild condition, it could be used for the synthesis of alkaline sensitive oligonucleotides. Trithymidinyl dicarbonate and dithymidinyl sulfite were synthesized in this report.

Key words: ALLYL GROUP, OLIGONUCLEOTIDE, PROTECTIVE GROUP, HYDROXY GROUP, PALLADIUM CHLORIDE

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Zhou Ying;Zhang Liangren;Zhang Lihe. Allyl as aprotective group for the synthesis of modified oligonucleotides[J]. Acta Chimica Sinica, 2001, 59(10): 1691-1696.

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烯丙基作为保护基在修饰寡核苷酸合成中的应用

Allyl as aprotective group for the synthesis of modified oligonucleotides

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