Platinum(II) complexes of [Pt(N~4,N~7-ribavirin)(DMSO)Cl] and [Pt (N~4,N~7-deoxyribavirin)-(DMSO)Cl] were prepared by the reactions of cis-[Pt(DMSO)_2Cl_2] or K[Pt (DMSO)Cl_3] with 1-β-D-ribofuranosyl-1,2, 4-triazole-3-carboxamide and its deoxyanalogue in buffer with good yields. The preparation of 1-(2'-deoxy-β-D-ribofuranosyl)-1,2,4- triazole-3-carboxamide was also performed through a four-step procedure, including protection of 3',5'-dihydroxyl group of ribavirin with 1,3- dichloro-1,1,3,3-tetraisopropyl-disiloxane, phenoxythiocarbonylation of the 2'-hydroxyl group of 3',5'-O-TPDS-ribavirin with phenoxythiocarbonylchloride, reduction of 2'-O-phenoxythiocarbonyl ester of 3',5'-O-TPDS-ribavirin with trin-butyltin hydride and AIBN, and deprotection of 3',5'-O-TPDS-ribavirin with tetrabutylammonium fluoride in THF.

Key words: PLATINUM COMPLEX, TRIBAVIRIN, FURAN P, AMIDES P, ACYL CHLORIDES, GLYOXALINE